Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Identifieur interne : 002A79 ( Main/Exploration ); précédent : 002A78; suivant : 002A80Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Auteurs : Jennifer Stone [Australie] ; Deborah J. Thompson [Royaume-Uni] ; Isabel Dos Santos Silva [Royaume-Uni] ; Christopher Scott [États-Unis] ; Rulla M. Tamimi [États-Unis] ; Sara Lindstrom [États-Unis] ; Peter Kraft [États-Unis] ; Aditi Hazra [États-Unis] ; Jingmei Li [Singapour] ; Louise Eriksson [Suède] ; Kamila Czene [Suède] ; Per Hall [Suède] ; Matt Jensen [États-Unis] ; Julie Cunningham [États-Unis] ; Janet E. Olson [États-Unis] ; Kristen Purrington [États-Unis] ; Fergus J. Couch [États-Unis] ; Judith Brown [Royaume-Uni] ; Jean Leyland [Royaume-Uni] ; Ruth M L. Warren [Royaume-Uni] ; Robert N. Luben [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Paula Smith [Royaume-Uni] ; Nicholas J. Wareham [Royaume-Uni] ; Sebastian M. Jud [Allemagne] ; Katharina Heusinger [Allemagne] ; Matthias W. Beckmann [Allemagne] ; Julie A. Douglas [États-Unis] ; Kaanan P. Shah [États-Unis] ; Heang-Ping Chan [États-Unis] ; Mark A. Helvie [États-Unis] ; Loic Le Marchand [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Christy Woolcott [Canada] ; Gertraud Maskarinec [États-Unis] ; Christopher Haiman [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [France] ; Kavitha Krishnan [Australie] ; Melissa C. Southey [Australie] ; Carmel Apicella [Australie] ; Irene L. Andrulis [Canada] ; Julia A. Knight [Canada] ; Giske Ursin [États-Unis] ; Grethe I Grenaker Alnaes [Norvège] ; Vessela N. Kristensen [Norvège] ; Anne-Lise Borresen-Dale [Norvège] ; Inger Torhild Gram [Norvège] ; Manjeet K. Bolla [Royaume-Uni] ; Qin Wang [Norvège] ; Kyriaki Michailidou [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Jacques Simard [Canada] ; Paul Pharoah [Royaume-Uni] ; Alison M. Dunning [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni] ; Peter A. Fasching [États-Unis] ; V Shane Pankratz [États-Unis] ; John L. Hopper [Australie] ; Celine M. Vachon [États-Unis]Source :
- Cancer research [ 1538-7445 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Densité mammaire, Facteurs de risque, Femelle, Glandes mammaires humaines (anatomopathologie), Glandes mammaires humaines (malformations), Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie, Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique), Tumeurs du sein (épidémiologie).
- MESH :
- anatomopathologie : Glandes mammaires humaines, Tumeurs du sein.
- génétique : Tumeurs du sein.
- malformations : Glandes mammaires humaines.
- épidémiologie : Tumeurs du sein.
- Adulte d'âge moyen, Densité mammaire, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie.
English descriptors
- KwdEn :
- Aged, Breast Density, Breast Neoplasms (epidemiology), Breast Neoplasms (genetics), Breast Neoplasms (pathology), Disease Susceptibility, Female, Genetic Predisposition to Disease, Genotype, Humans, Mammary Glands, Human (abnormalities), Mammary Glands, Human (pathology), Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
- MESH :
- abnormalities : Mammary Glands, Human.
- epidemiology : Breast Neoplasms.
- genetics : Breast Neoplasms.
- pathology : Breast Neoplasms, Mammary Glands, Human.
- Aged, Breast Density, Disease Susceptibility, Female, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk, but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute nondense area adjusted for study, age, and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1), and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all P < 10(-5)). Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively. There were associations between rs6001930 (MKL1) and both adjusted absolute dense and nondense areas, and between rs17356907 (NTN4) and adjusted absolute nondense area. Trends in all but two associations were consistent with those for breast cancer risk. Results suggested that 18% of breast cancer susceptibility variants were associated with at least one mammographic density measure. Genetic variants at multiple loci were associated with both breast cancer risk and the mammographic density measures. Further understanding of the underlying mechanisms at these loci could help identify etiologic pathways implicated in how mammographic density predicts breast cancer risk.
DOI: 10.1158/0008-5472.CAN-14-2012
PubMed: 25862352
Affiliations:
- Allemagne, Australie, Canada, France, Norvège, Royaume-Uni, Singapour, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Californie, Grand Londres, Hawaï, Massachusetts, Michigan, Minnesota, Ontario, Svealand, Victoria (État), Østlandet
- Cambridge, Londres, Melbourne, Oslo, Stockholm, Toronto
- Université de Cambridge, Université de Melbourne, Université de Toronto
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Thompson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M" last="Tamimi">Rulla M. Tamimi</name><affiliation wicri:level="2"><nlm:affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Jensen, Matt" sort="Jensen, Matt" uniqKey="Jensen M" first="Matt" last="Jensen">Matt Jensen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Cunningham, Julie" sort="Cunningham, Julie" uniqKey="Cunningham J" first="Julie" last="Cunningham">Julie Cunningham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Warren, Ruth M L" sort="Warren, Ruth M L" uniqKey="Warren R" first="Ruth M L" last="Warren">Ruth M L. Warren</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiology, University of Cambridge, Addenbrooke's NHS Foundation Trust, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Radiology, University of Cambridge, Addenbrooke's NHS Foundation Trust, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:affiliation>MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Smith, Paula" sort="Smith, Paula" uniqKey="Smith P" first="Paula" last="Smith">Paula Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="4"><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M" last="Jud">Sebastian M. Jud</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Douglas, Julie A" sort="Douglas, Julie A" uniqKey="Douglas J" first="Julie A" last="Douglas">Julie A. Douglas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Human Genetics, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Shah, Kaanan P" sort="Shah, Kaanan P" uniqKey="Shah K" first="Kaanan P" last="Shah">Kaanan P. Shah</name><affiliation wicri:level="2"><nlm:affiliation>Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Human Genetics, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Chan, Heang Ping" sort="Chan, Heang Ping" uniqKey="Chan H" first="Heang-Ping" last="Chan">Heang-Ping Chan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Helvie, Mark A" sort="Helvie, Mark A" uniqKey="Helvie M" first="Mark A" last="Helvie">Mark A. Helvie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Genecology, IWK Health Centre, Halifax, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics and Genecology, IWK Health Centre, Halifax</wicri:regionArea><wicri:noRegion>Halifax</wicri:noRegion></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name><affiliation wicri:level="2"><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, Villejuif Cedex, France. Paris-South University, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, Villejuif Cedex, France. Paris-South University, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="4"><nlm:affiliation>Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation wicri:level="4"><nlm:affiliation>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation wicri:level="2"><nlm:affiliation>Institute of Basic Medical Sciences, University of Oslo, Norway. Department of Preventive Medicine, University of Southern California, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Institute of Basic Medical Sciences, University of Oslo, Norway. Department of Preventive Medicine, University of Southern California</wicri:cityArea></affiliation></author><author><name sortKey="Alnaes, Grethe I Grenaker" sort="Alnaes, Grethe I Grenaker" uniqKey="Alnaes G" first="Grethe I Grenaker" last="Alnaes">Grethe I Grenaker Alnaes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N" last="Kristensen">Vessela N. Kristensen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="2"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M" last="Vachon">Celine M. Vachon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. vachon.celine@mayo.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25862352</idno><idno type="pmid">25862352</idno><idno type="doi">10.1158/0008-5472.CAN-14-2012</idno><idno type="wicri:Area/PubMed/Corpus">002C75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C75</idno><idno type="wicri:Area/PubMed/Curation">002C01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C01</idno><idno type="wicri:Area/PubMed/Checkpoint">002C01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C01</idno><idno type="wicri:Area/Ncbi/Merge">002440</idno><idno type="wicri:Area/Ncbi/Curation">002440</idno><idno type="wicri:Area/Ncbi/Checkpoint">002440</idno><idno type="wicri:Area/Main/Merge">002A79</idno><idno type="wicri:Area/Main/Curation">002A79</idno><idno type="wicri:Area/Main/Exploration">002A79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.</title><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J" last="Thompson">Deborah J. Thompson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M" last="Tamimi">Rulla M. Tamimi</name><affiliation wicri:level="2"><nlm:affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Jensen, Matt" sort="Jensen, Matt" uniqKey="Jensen M" first="Matt" last="Jensen">Matt Jensen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Cunningham, Julie" sort="Cunningham, Julie" uniqKey="Cunningham J" first="Julie" last="Cunningham">Julie Cunningham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Warren, Ruth M L" sort="Warren, Ruth M L" uniqKey="Warren R" first="Ruth M L" last="Warren">Ruth M L. Warren</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiology, University of Cambridge, Addenbrooke's NHS Foundation Trust, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Radiology, University of Cambridge, Addenbrooke's NHS Foundation Trust, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:affiliation>MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Smith, Paula" sort="Smith, Paula" uniqKey="Smith P" first="Paula" last="Smith">Paula Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="4"><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M" last="Jud">Sebastian M. Jud</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Douglas, Julie A" sort="Douglas, Julie A" uniqKey="Douglas J" first="Julie A" last="Douglas">Julie A. Douglas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Human Genetics, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Shah, Kaanan P" sort="Shah, Kaanan P" uniqKey="Shah K" first="Kaanan P" last="Shah">Kaanan P. Shah</name><affiliation wicri:level="2"><nlm:affiliation>Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Human Genetics, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Chan, Heang Ping" sort="Chan, Heang Ping" uniqKey="Chan H" first="Heang-Ping" last="Chan">Heang-Ping Chan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Helvie, Mark A" sort="Helvie, Mark A" uniqKey="Helvie M" first="Mark A" last="Helvie">Mark A. Helvie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Genecology, IWK Health Centre, Halifax, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics and Genecology, IWK Health Centre, Halifax</wicri:regionArea><wicri:noRegion>Halifax</wicri:noRegion></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation wicri:level="2"><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name><affiliation wicri:level="2"><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, Villejuif Cedex, France. Paris-South University, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, Villejuif Cedex, France. Paris-South University, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="4"><nlm:affiliation>Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation wicri:level="4"><nlm:affiliation>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation wicri:level="2"><nlm:affiliation>Institute of Basic Medical Sciences, University of Oslo, Norway. Department of Preventive Medicine, University of Southern California, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Institute of Basic Medical Sciences, University of Oslo, Norway. Department of Preventive Medicine, University of Southern California</wicri:cityArea></affiliation></author><author><name sortKey="Alnaes, Grethe I Grenaker" sort="Alnaes, Grethe I Grenaker" uniqKey="Alnaes G" first="Grethe I Grenaker" last="Alnaes">Grethe I Grenaker Alnaes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N" last="Kristensen">Vessela N. Kristensen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="2"><nlm:affiliation>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M" last="Vachon">Celine M. Vachon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. vachon.celine@mayo.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Breast Density</term><term>Breast Neoplasms (epidemiology)</term><term>Breast Neoplasms (genetics)</term><term>Breast Neoplasms (pathology)</term><term>Disease Susceptibility</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Mammary Glands, Human (abnormalities)</term><term>Mammary Glands, Human (pathology)</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Densité mammaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Glandes mammaires humaines (anatomopathologie)</term><term>Glandes mammaires humaines (malformations)</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Susceptibilité à une maladie</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (génétique)</term><term>Tumeurs du sein (épidémiologie)</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Mammary Glands, Human</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Glandes mammaires humaines</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Glandes mammaires humaines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Mammary Glands, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Breast Density</term><term>Disease Susceptibility</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Densité mammaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Susceptibilité à une maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk, but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute nondense area adjusted for study, age, and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1), and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all P < 10(-5)). Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively. There were associations between rs6001930 (MKL1) and both adjusted absolute dense and nondense areas, and between rs17356907 (NTN4) and adjusted absolute nondense area. Trends in all but two associations were consistent with those for breast cancer risk. Results suggested that 18% of breast cancer susceptibility variants were associated with at least one mammographic density measure. Genetic variants at multiple loci were associated with both breast cancer risk and the mammographic density measures. Further understanding of the underlying mechanisms at these loci could help identify etiologic pathways implicated in how mammographic density predicts breast cancer risk.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Norvège</li><li>Royaume-Uni</li><li>Singapour</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Californie</li><li>Grand Londres</li><li>Hawaï</li><li>Massachusetts</li><li>Michigan</li><li>Minnesota</li><li>Ontario</li><li>Svealand</li><li>Victoria (État)</li><li>Østlandet</li></region><settlement><li>Cambridge</li><li>Londres</li><li>Melbourne</li><li>Oslo</li><li>Stockholm</li><li>Toronto</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Melbourne</li><li>Université de Toronto</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name></noRegion><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J" last="Thompson">Deborah J. Thompson</name></region><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><name sortKey="Smith, Paula" sort="Smith, Paula" uniqKey="Smith P" first="Paula" last="Smith">Paula Smith</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><name sortKey="Warren, Ruth M L" sort="Warren, Ruth M L" uniqKey="Warren R" first="Ruth M L" last="Warren">Ruth M L. Warren</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name></region><name sortKey="Chan, Heang Ping" sort="Chan, Heang Ping" uniqKey="Chan H" first="Heang-Ping" last="Chan">Heang-Ping Chan</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><name sortKey="Cunningham, Julie" sort="Cunningham, Julie" uniqKey="Cunningham J" first="Julie" last="Cunningham">Julie Cunningham</name><name sortKey="Douglas, Julie A" sort="Douglas, Julie A" uniqKey="Douglas J" first="Julie A" last="Douglas">Julie A. Douglas</name><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Helvie, Mark A" sort="Helvie, Mark A" uniqKey="Helvie M" first="Mark A" last="Helvie">Mark A. Helvie</name><name sortKey="Jensen, Matt" sort="Jensen, Matt" uniqKey="Jensen M" first="Matt" last="Jensen">Matt Jensen</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><name sortKey="Shah, Kaanan P" sort="Shah, Kaanan P" uniqKey="Shah K" first="Kaanan P" last="Shah">Kaanan P. Shah</name><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M" last="Tamimi">Rulla M. Tamimi</name><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M" last="Vachon">Celine M. Vachon</name></country><country name="Singapour"><noRegion><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name></region><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></country><country name="Allemagne"><noRegion><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M" last="Jud">Sebastian M. Jud</name></noRegion><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name></country><country name="Canada"><noRegion><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name></noRegion><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></country><country name="France"><region name="Victoria (État)"><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></region></country><country name="Norvège"><region name="Østlandet"><name sortKey="Alnaes, Grethe I Grenaker" sort="Alnaes, Grethe I Grenaker" uniqKey="Alnaes G" first="Grethe I Grenaker" last="Alnaes">Grethe I Grenaker Alnaes</name></region><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N" last="Kristensen">Vessela N. Kristensen</name><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
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